Examining the frontal subcortical brain vulnerability hypothesis in children with neurofibromatosis type 1: are T2-weighted hyperintensities related to executive dysfunction?

Arnaud Roy (1) , Didier Le Gall (1) , Sébastien Barbarot , Valérie Charbonnier , Marie Gayet-Delacroix , Jean-François Stalder , Jean-Luc Roulin

1 LPPL - Laboratoire de Psychologie des Pays de la Loire

It was hypothesized that neuropsychological impairments in children with neurofibromatosis type I (NF1) are associated with brain areas of increased T2-weighted signal intensity on MRI. Systematic and extensive examination of this hypothesis remains however scarce, particularly regarding executive dysfunction whereas hyperintensities are located preferentially in frontal-sub-cortical networks. In this study, we compared the executive functioning profile with characteristics of brain hyperintensities in children with NF1.

Keywords: Cognition Disorders; Brain Mapping/methods; Neuropsychological Tests; Executive Function/physiology

Domains: Neuroscience

Arnaud Roy, Didier Le Gall, Sébastien Barbarot, Valérie Charbonnier, Marie Gayet-Delacroix, et al.. Examining the frontal subcortical brain vulnerability hypothesis in children with neurofibromatosis type 1: are T2-weighted hyperintensities related to executive dysfunction?. Neuropsychology, 2015, 29 (3), pp.473-484. ⟨10.1037/neu0000151⟩. ⟨hal-03329608⟩