Hypovitaminosis D in pregnancy in the Mediterranean region : a systematic review - Nantes Université Access content directly
Journal Articles European Journal of Clinical Nutrition Year : 2016

Hypovitaminosis D in pregnancy in the Mediterranean region : a systematic review

S Karras
  • Function : Author
S Paschou
  • Function : Author
E Kandaraki
  • Function : Author
P Anagnostis
  • Function : Author
B Tarlatzis
  • Function : Author
B Hollis
  • Function : Author
W Grant
  • Function : Author
D Goulis
  • Function : Author


Despite high levels of sunshine, maternal hypovitaminosis D during pregnancy is prevalent in the Mediterranean region. The aim of this study is to systematically review trials that investigated vitamin D concentrations during pregnancy in this region, in order to determine predictors of hypovitaminosis D and explain this phenomenon. After applying inclusion/exclusion criteria, 15 studies were entered into the systematic review involving 2649 pregnant women and 820 neonates. The main outcome was maternal vitamin D status, assessed by serum 25-hydroxy-vitamin D (25(OH)D) concentrations. Possible predictors of the outcome included maternal age, body mass index (BMI), race, socioeconomic status, skin type, gestational age, sun exposure, calcium and vitamin D intake and supplementation, smoking status, parity and season of delivery. Studies differed widely in vitamin D deficiency criteria, method of measurement and outcomes. The prevalence of vitamin D insufficiency ranges from 9.3 to 41.4%, whereas that of vitamin D deficiency from 22.7 to 90.3%. A positive association with 25(OH)D concentrations exists for light skin color, white race, uncovered dressing pattern, maternal vitamin D supplementation and season of gestation (spring/summer). An inverse association exists for BMI and gestational age, whereas data for smoking and socioeconomic status are controversial. We concluded that vitamin D deficiency in pregnancy seems to be quite common, even in the Mediterranean region. Racial, social and cultural habits, as well as the absence of preventive supplementation/dietary strategies, seem to negate the benefits of sun exposure.

Dates and versions

hal-03298009 , version 1 (23-07-2021)



Cédric Annweiler, S Karras, S Paschou, E Kandaraki, P Anagnostis, et al.. Hypovitaminosis D in pregnancy in the Mediterranean region : a systematic review. European Journal of Clinical Nutrition, 2016, 70 (9), pp.979-986. ⟨10.1038/ejcn.2016.12⟩. ⟨hal-03298009⟩
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