Expression of fucosylated glycans in endothelial glycocalyces of placental villi at early and late fetal growth restriction

M.M. Ziganshina (1) , G.V. Kulikova (1) , N.M. Fayzullina (1) , E.L. Yarotskaya (1) , A.I. Shchegolev (1) , Jacques Le Pendu (2) , Adrien Breiman (2) , N.V. Shilova (1, 3) , N.R. Khasbiullina (1) , N.V. Bovin (3) , N.E. Kan (1) , V.L. Tyutyunnik (1) , Z.S. Khodzhaeva (1, 4) , G.T. Sukhikh (1, 5)

1 National Medical Research Center for Obstetrics, Gynecology and Perinatology [Moscow, Russia]
2 CRCINA-ÉQUIPE 5 - Host-Pathogen Interactions in the Regulation of Immune Responses
3 The M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry [Moscow, Russia]
4 The N.D. Zelinsky Institute of Organic Chemistry [Moscow, Russia]
5 Federal State Autonomous Educational Institution of Higher Education [Moscow, Russia]

The aim of the study was to investigate the content and distribution of fucosylated sugar residues and Lewis Y (LeY) in the endothelial glycocalyx (eGC) in placental tissue at early and late onset fetal growth restriction (FGR). Our findings demonstrated that the changes of the fucosylated glycans of type 2 (H2)/LeY in the vascular endothelium of the villi may reflect alteration of villi maturation, or adaptation to hypoxia through the change of cell proliferation potential and induction angiogenesis. Early onset FGR differs from late onset FGR by a markedly increased LeY expression, being associated with more severe pathological state.

Mots clés: Glycocalyx; Fucosylated glycans; Lectin histochemistry; Placenta; Fetal growth restriction

Domaines: Cancer

M.M. Ziganshina, G.V. Kulikova, N.M. Fayzullina, E.L. Yarotskaya, A.I. Shchegolev, et al.. Expression of fucosylated glycans in endothelial glycocalyces of placental villi at early and late fetal growth restriction. Placenta, 2019, 90, pp.98-102. ⟨10.1016/j.placenta.2019.12.005⟩. ⟨inserm-02426291⟩