Developing Consensus-Based Priority Outcome Domains for Trials in Kidney Transplantation: A Multinational Delphi Survey With Patients, Caregivers, and Health Professionals - Université de Nantes Accéder directement au contenu
Article Dans Une Revue Transplantation Année : 2017

Developing Consensus-Based Priority Outcome Domains for Trials in Kidney Transplantation: A Multinational Delphi Survey With Patients, Caregivers, and Health Professionals

Allison Tong
  • Fonction : Auteur
Karine E. Manera
  • Fonction : Auteur
Jeremy R. Chapman
  • Fonction : Auteur
Anthony N. Warrens
  • Fonction : Auteur
David Rosenbloom
  • Fonction : Auteur
Germaine Wong
  • Fonction : Auteur
John Gill
  • Fonction : Auteur
Klemens Budde
  • Fonction : Auteur
Lionel Rostaing
Lorna Marson
  • Fonction : Auteur
Michelle A. Josephson
  • Fonction : Auteur
Peter P. Reese
  • Fonction : Auteur
Timothy L. Pruett
  • Fonction : Auteur
Camilla S. Hanson
  • Fonction : Auteur
Donal O'Donoghue
  • Fonction : Auteur
Helen Tam-Tham
  • Fonction : Auteur
Jean-Michel Halimi
Jenny I. Shen
  • Fonction : Auteur
John Kanellis
  • Fonction : Auteur
John D. Scandling
  • Fonction : Auteur
Kirsten Howard
  • Fonction : Auteur
Martin Howell
  • Fonction : Auteur
Nick Cross
  • Fonction : Auteur
Nicole Evangelidis
  • Fonction : Auteur
Philip Masson
  • Fonction : Auteur
Rainer Oberbauer
  • Fonction : Auteur
Samuel Fung
  • Fonction : Auteur
Shilpa Jesudason
  • Fonction : Auteur
Simon Knight
  • Fonction : Auteur
Sreedhar Mandayam
  • Fonction : Auteur
Stephen P. Mcdonald
  • Fonction : Auteur
Steve Chadban
  • Fonction : Auteur
Tasleem Rajan
  • Fonction : Auteur
Jonathan C. Craig
  • Fonction : Auteur

Résumé

BACKGROUND: Inconsistencies in outcome reporting and frequent omission of patient-centered outcomes can diminish the value of trials in treatment decision making. We identified critically important outcome domains in kidney transplantation based on the shared priorities of patients/caregivers and health professionals. METHODS: In a 3-round Delphi survey, patients/caregivers and health professionals rated the importance of outcome domains for trials in kidney transplantation on a 9-point Likert scale and provided comments. During rounds 2 and 3, participants rerated the outcomes after reviewing their own score, the distribution of the respondents' scores, and comments. We calculated the median, mean, and proportion rating 7 to 9 (critically important), and analyzed comments thematically. RESULTS: One thousand eighteen participants (461 [45%] patients/caregivers and 557 [55%] health professionals) from 79 countries completed round 1, and 779 (77%) completed round 3. The top 8 outcomes that met the consensus criteria in round 3 (mean, ≥q7.5; median, ≥q8; proportion, >85%) in both groups were graft loss, graft function, chronic rejection, acute rejection, mortality, infection, cancer (excluding skin), and cardiovascular disease. Compared with health professionals, patients/caregivers gave higher priority to 6 outcomes (mean difference of 0.5 or more): skin cancer, surgical complications, cognition, blood pressure, depression, and ability to work. We identified 5 themes: capacity to control and inevitability, personal relevance, debilitating repercussions, gaining awareness of risks, and addressing knowledge gaps. CONCLUSIONS: Graft complications and severe comorbidities were critically important for both stakeholder groups. These stakeholder-prioritized outcomes will inform the core outcome set to improve the consistency and relevance of trials in kidney transplantation.

Dates et versions

hal-03158157 , version 1 (03-03-2021)

Identifiants

Citer

Bénédicte Sautenet, Allison Tong, Karine E. Manera, Jeremy R. Chapman, Anthony N. Warrens, et al.. Developing Consensus-Based Priority Outcome Domains for Trials in Kidney Transplantation: A Multinational Delphi Survey With Patients, Caregivers, and Health Professionals. Transplantation, 2017, 101 (8), pp.1875-1886. ⟨10.1097/TP.0000000000001776⟩. ⟨hal-03158157⟩
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