Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: Potent and selective aromatase inhibitors

Marie-Pierre Lézé (1) , Marc Le Borgne (1) , Patricia Pinson (1) , Anja Palusczak (2) , Muriel Duflos (1) , Guillaume Le Baut (1) , Rolf W Hartmann (2)

1 IICiMed - Cibles et Médicaments des Infections et de l'Immunité
2 Saarland University [Saarbrücken]

Domaines: Chimie thérapeutique

Marie-Pierre Lézé, Marc Le Borgne, Patricia Pinson, Anja Palusczak, Muriel Duflos, et al.. Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: Potent and selective aromatase inhibitors. Bioorganic and Medicinal Chemistry Letters, 2006, 16 (5), pp.1134 - 1137. ⟨10.1016/j.bmcl.2005.11.099⟩. ⟨hal-01689230⟩