Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells

Julien Defaux (1) , Maud Antoine (1) , Cédric Logé (1) , Marc Le Borgne (1) , Tilmann Schuster (2) , Irene Seipelt (2) , Babette Aicher (2) , Michael Teifel (2) , Eckhard Günther (2) , Matthias Gerlach (2) , Pascal Marchand (1)

1 IICiMed - Cibles et Médicaments des Infections et de l'Immunité
2 Aeterna-Zentaris

Domaines: Chimie thérapeutique; Cancer; Biologie cellulaire; Sciences pharmaceutiques

Julien Defaux, Maud Antoine, Cédric Logé, Marc Le Borgne, Tilmann Schuster, et al.. Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells. Bioorganic and Medicinal Chemistry Letters, 2014, 24 (16), pp.3748 - 3752. ⟨10.1016/j.bmcl.2014.06.078⟩. ⟨hal-01683305⟩