Skin manifestations of monoclonal gammopathies

Manifestations cutanées associées aux gammapathies monoclonales [Skin manifestations of monoclonal gammopathies]

M. Hello , S. Barbarot , A. Néel (1, 2) , J. Connault , J. Graveleau , C. Durant (3) , O. Decaux (4) , M. Hamidou (5)

1 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
2 ITUN - Institut de transplantation urologie-néphrologie
3 Service de Médecine Interne
4 Centre Hospitalier Universitaire [Rennes]
5 Département d'Hydraulique [M’Sila]

Whatever their aetiology, monoclonal gammopathies can be associated to several clinical features. Mechanisms are various and sometimes unknown. Skin is frequently involved and may represent a challenging diagnosis. Indeed, skin manifestations are either the presenting features and isolated, or at the background of a systemic syndrome. Our objective was to review the various skin manifestations that have been associated with monoclonal gammopathies.

Mots clés: Autoimmune Diseases; Autoantibodies; Amyloidosis; Cryoglobulinemia; Immunoglobulins; Humans; Cutis Laxa; Vesiculobullous; Skin Diseases; Skin; Paraproteinemias; POEMS Syndrome

Domaines: Sciences du Vivant [q-bio]

M. Hello, S. Barbarot, A. Néel, J. Connault, J. Graveleau, et al.. Manifestations cutanées associées aux gammapathies monoclonales [Skin manifestations of monoclonal gammopathies]. La Revue de Médecine Interne, 2014, 35 (1), pp.28--38. ⟨10.1016/j.revmed.2013.08.014⟩. ⟨hal-01064929⟩